Research Opportunity: DNA-Protein Epigenetic Chemistry Engineering (D-PECHE)
Issuing Agency:DEPT OF DEFENSE - DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) (Virginia)
Solicitation ID:sam_553632b7e7fd49a7884a1c32f8a611c5
RFP Description
Location: Virginia. UPDATE: The purpose of Amendment 1 to DARPA-SN-26-67, the DNA-Protein Epigenetic Chemistry Engineering (D-PECHE) Special Notice (SN), is to clarify submission instructions and deadlines. The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to demonstrate proof-of-concept for novel mechanisms for writing and erasing epigenetic base modifications in DNA. Mechanisms capable of modifying the epigenome offer new opportunities to control DNA-protein interactions and to study the functions and applications of rare or novel epigenetic modifications. This research opportunity will result in demonstrations of novel technologies to modify nucleic acids in vitro.
How to Win This Contract
This is an open market solicitation. Since it is open to all qualified contractors, competition may be high. Differentiating your technical response and offering a highly compliant proposal structure will be key to winning. For projects of this size, having clear, compliant documentation and showing immediately available resources to execute the work is the fastest path to selection by DEPT OF DEFENSE - DEFENSE ADVANCED RESEARCH PROJECTS AGENCY (DARPA) (Virginia). Ensure all bid packages, attachments, and compliance affidavits are completed and uploaded to samgov before the closing deadline on 6/24/2026.
Want to submit a winning proposal for this contract?
Stronger Built's proposal consulting team acts as your in-house bid desk. We parse the statement of work, draft compliant responses, compile set-aside certs, and manage submission. With our Pay-When-You-Win model, you mostly pay us only when your business wins.